Protective effect of a natural herb (Rosmarinus officinalis) against hepatotoxicity in male albino rats

Abdel-Wahhab, Khaled Gamal El-Deen; El-Shamy, Karima Abbas; El-Beih, Nadia Abd El-Zizz; Morcy, Fatma Adly; Mannaa, Fathia Abd Elwahid

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dc.creator	Abdel-Wahhab, Khaled Gamal El-Deen
dc.creator	El-Shamy, Karima Abbas
dc.creator	El-Beih, Nadia Abd El-Zizz
dc.creator	Morcy, Fatma Adly
dc.creator	Mannaa, Fathia Abd Elwahid
dc.date	2011-04-19
dc.date.accessioned	2022-03-21T20:06:56Z
dc.date.available	2022-03-21T20:06:56Z
dc.identifier	https://comunicatascientiae.com.br/comunicata/article/view/82
dc.identifier	10.14295/cs.v2i1.82
dc.identifier.uri	http://biblioteca-repositorio.clacso.edu.ar/handle/CLACSO/77514
dc.description	The present study was conducted to study the chemoprotective effect of Egyptian rosemary extract (RE) against CCl4-induced hepatotoxicity. Eight experimental groups were used as follow: (1) control; (2&3) RE alone (440 mg/kgb.w) for 4 and 8 weeks, respectively; (4) CCl4 (1ml/kg b.w, twice a week, i.p) for 4 weeks; (5&7) RE (220&440 mg/kg) for 4 weeks before CCl4 for a similar period; and (6&8) RE (220&440 mg/kg) for four weeks before CCl4 in combination with RE another four weeks. The sequential CCl4 treatment induced significant changes in serum biochemical parameters accompanied by sever histological and histochemical changes of the liver tissue, while administration of 440 mg/kg/day for either 4 or 8 weeks did not induce any changes. Administration of RE before or during the treatment with CCl4 improved all biochemical parameters and histological picture of the liver, in a dose and duration-dependant manner. It could be concluded that RE has a protective effects against hepatotoxicity.	en-US
dc.description	The present study was conducted to study the chemoprotective effect of Egyptian rosemary extract (RE) against CCl4-induced hepatotoxicity. Eight experimental groups were used as follow: (1) control; (2&3) RE alone (440 mg/kgb.w) for 4 and 8 weeks, respectively; (4) CCl4 (1ml/kg b.w, twice a week, i.p) for 4 weeks; (5&7) RE (220&440 mg/kg) for 4 weeks before CCl4 for a similar period; and (6&8) RE (220&440 mg/kg) for four weeks before CCl4 in combination with RE another four weeks. The sequential CCl4 treatment induced significant changes in serum biochemical parameters accompanied by sever histological and histochemical changes of the liver tissue, while administration of 440 mg/kg/day for either 4 or 8 weeks did not induce any changes. Administration of RE before or during the treatment with CCl4 improved all biochemical parameters and histological picture of the liver, in a dose and duration-dependant manner. It could be concluded that RE has a protective effects against hepatotoxicity. Efeito protetor de erva natural (Rosmarinus officinalis) contrahepatotoxicidade em ratos albinos machosResumoO presente estudo foi realizado para verificar o efeito quimioprotetor do extrato de alecrim egípcio(RE) contra toxidade hepática induzida por CCl4-. Oito grupos experimentais foram utilizados, comosegue: (1) controle; (2&3) apenas RE (440 mg/kgb.w) por 4 e 8 semanas, respectivamente; (4) CCl4(1ml/kg b.w, duas vezes por semana, i.p) durante 4 semanas; (5&7) RE (220&440 mg/kg) por quatrosemanas antes de CCl4 por um período similar; e(6&8) RE (220&440 mg/kg) por quatro semanasantes de CCl4 combinado com RE por outras quatro semanas. O tratamento seqüencial de CCl4induziu mudanças significativas nos parâmetros bioquímicos do soro, acompanhadas por severasmudanças histológicas e histoquímicas no tecido do fígado, enquanto que a administração de 440mg/kg/dia durante 4 ou 8 semanas não induziu nenhuma mudança. A administração de RE antesou durante o tratamento com CCl4 aumentou os parâmetros bioquímicos e histológicos do fígado,dependendo da dose e de sua duração. Pode-se concluir que RE apresenta efeito de proteçãocontra a toxidade hepática.	pt-BR
dc.format	application/pdf
dc.language	por
dc.publisher	Federal University of Piauí	en-US
dc.relation	https://comunicatascientiae.com.br/comunicata/article/view/82/59
dc.source	Comunicata Scientiae; Vol. 2 No. 1 (2011); 9-17	en-US
dc.source	Comunicata Scientiae; v. 2 n. 1 (2011); 9-17	pt-BR
dc.source	2177-5133
dc.source	2176-9079
dc.subject	Rosemary extract	en-US
dc.subject	hepatotoxicity	en-US
dc.subject	carbon tetrachloride	en-US
dc.subject	liver function	en-US
dc.subject	Rosemary extract	pt-BR
dc.subject	hepatotoxicity	pt-BR
dc.subject	carbon tetrachloride	pt-BR
dc.subject	liver function	pt-BR
dc.title	Protective effect of a natural herb (Rosmarinus officinalis) against hepatotoxicity in male albino rats	en-US
dc.title	Protective effect of a natural herb (Rosmarinus officinalis) against hepatotoxicity in male albino rats	pt-BR
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion