Glycoalkaloids as medicinal agents from callus and regenerated plants of Solanum nigrum var. judaicum

Al-Ashaal, Hanan Abd Al-Hay

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dc.creator	Al-Ashaal, Hanan Abd Al-Hay
dc.date	2019-10-31
dc.date.accessioned	2023-03-30T19:35:12Z
dc.date.available	2023-03-30T19:35:12Z
dc.identifier	https://comunicatascientiae.com.br/comunicata/article/view/2840
dc.identifier	10.14295/cs.v10i3.2840
dc.identifier.uri	https://biblioteca-repositorio.clacso.edu.ar/handle/CLACSO/246815
dc.description	The target of this study is production of glycoalkaloids from cultures of Solanum nigrum var. judaicum Besser. Further, to evaluate their therapeutic effects. S. nigrum var. judaicum leaves were implanted in MS media containing growth regulators for in vitro study. HPLC analyses were applied for qualitative and quantitative determination of glycoalkaloids. Cytotoxic effects against human carcinoma cell lines were evaluated. In addition, antiviral, antioxidant, anti-inflammatory and antiparasitic activities of the formed glycoalkaloids were estimated.  HPLC data indicated the success of in vitro solasodine and solanidine glycosides production. Solasonine represented the highest concentration. Biological assays illustrated that obtained glycoalkaloids exhibited cytotoxic activity against human carcinoma cell lines that may be attributed to free radical scavenging activity (69.98%). Strong antiherps performance was observed (94%). In addition, the glycoalkaloids showed in vitro schistomicidal (IC50 76.4 ppm) and fasciolicidal (IC50 76.6 ppm) activities. In vivo anti-inflammatory assay revealed potent activity against carrageenan induced edema. Glycoalkaloids were formed 2-5 folds that of intact plant pointed to the efficiency of the cultures. The present findings referred to the pronounced biological performance of the produced glycoalkaloids including antiviral, cytotoxic anti-inflammatory and antiparasitic activities. Botanical derived medication from S. nigrum var. judaicum could be accomplished guided with the present data.	en-US
dc.description	The target of this study is production of glycoalkaloids from cultures of Solanum nigrum var. judaicum Besser. Further, to evaluate their therapeutic effects. S. nigrum var. judaicum leaves were implanted in MS media containing growth regulators for in vitro study. HPLC analyses were applied for qualitative and quantitative determination of glycoalkaloids. Cytotoxic effects against human carcinoma cell lines were evaluated. In addition, antiviral, antioxidant, anti-inflammatory and antiparasitic activities of the formed glycoalkaloids were estimated.  HPLC data indicated the success of in vitro solasodine and solanidine glycosides production. Solasonine represented the highest concentration. Biological assays illustrated that obtained glycoalkaloids exhibited cytotoxic activity against human carcinoma cell lines that may be attributed to free radical scavenging activity (69.98%). Strong antiherps performance was observed (94%). In addition, the glycoalkaloids showed in vitro schistomicidal (IC50 76.4 ppm) and fasciolicidal (IC50 76.6 ppm) activities. In vivo anti-inflammatory assay revealed potent activity against carrageenan induced edema. Glycoalkaloids were formed 2-5 folds that of intact plant pointed to the efficiency of the cultures. The present findings referred to the pronounced biological performance of the produced glycoalkaloids including antiviral, cytotoxic anti-inflammatory and antiparasitic activities. Botanical derived medication from S. nigrum var. judaicum could be accomplished guided with the present data.	pt-BR
dc.format	application/pdf
dc.language	eng
dc.publisher	Federal University of Piauí	en-US
dc.relation	https://comunicatascientiae.com.br/comunicata/article/view/2840/842
dc.rights	Copyright (c) 2019 Hanan Abd Al-Hay Al-Ashaal	en-US
dc.source	Comunicata Scientiae; Vol. 10 No. 3 (2019): Comunicata Scientiae; 325-337	en-US
dc.source	Comunicata Scientiae; v. 10 n. 3 (2019): Comunicata Scientiae; 325-337	pt-BR
dc.source	2177-5133
dc.source	2176-9079
dc.title	Glycoalkaloids as medicinal agents from callus and regenerated plants of Solanum nigrum var. judaicum	en-US
dc.title	Glycoalkaloids as medicinal agents from callus and regenerated plants of Solanum nigrum var. judaicum	pt-BR
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion