Tratamiento farmacológico antidepresivo en adultos mayores: Guía basada en síntesis de la evidencia

Porras Angarita, Henry Alberto

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dc.contributor	Villar Centeno, Juan Carlos
dc.contributor	Santacruz, José Manuel
dc.contributor	Villar Centeno, Juan Carlos [0000068519]
dc.contributor	Villar Centeno, Juan Carlos [0000-0002-7047-7299]
dc.contributor	Villar Centeno, Juan Carlos [Juan-Carlos-Villar-Centeno-2168464015]
dc.creator	Porras Angarita, Henry Alberto
dc.date	2021-08-12T13:36:29Z
dc.date	2021-08-12T13:36:29Z
dc.date	2021
dc.date.accessioned	2022-03-14T20:20:27Z
dc.date.available	2022-03-14T20:20:27Z
dc.identifier	http://hdl.handle.net/20.500.12749/13787
dc.identifier	instname:Universidad Autónoma de Bucaramanga - UNAB
dc.identifier	reponame:Repositorio Institucional UNAB
dc.identifier	repourl:https://repository.unab.edu.co
dc.identifier.uri	http://biblioteca-repositorio.clacso.edu.ar/handle/CLACSO/22429
dc.description	La depresión del adulto mayor es una patología con una alta prevalencia y complicaciones, en un grupo poblacional en constante crecimiento, que conlleva múltiples desafíos por la influencia de diferentes factores biopsicosociales que no están presentes en otros grupos poblacionales. Se asocia a un peor pronóstico, curso crónico, menor respuesta antidepresiva y mayor riesgo de recaída o recurrencia. El uso de fármacos antidepresivos en ancianos se ha correlacionado con efectos adversos importantes que podrían poner en riesgo la vida y que deben ser tenidos en cuenta a la hora de pautar el tratamiento. La información que actualmente existe en guías sobre el tratamiento farmacológico antidepresivo está centrada en la población general, no están basadas en evidencia o no están sintetizadas. Estas guías permiten transmitir la información de manera clara, sintetizada, y lleva a que los profesionales de la salud puedan tomar decisiones terapéuticas de manera más rápida, evitar complicaciones, prevenir un uso inapropiado de fármacos y mejorar las pautas de tratamiento en beneficio del adulto mayor.
dc.description	1. TÍTULO DEL PROYECTO 10 2. RESUMEN 10 3. DESCRIPCIÓN DEL PROYECTO 14 3.1. PLANTEAMIENTO DEL PROBLEMA DE INVESTIGACIÓN Y SU JUSTIFICACIÓN EN TÉRMINOS DE NECESIDADES Y PERTINENCIA 14 3.2. MARCO TEORICO 18 3.3. ESTADO DEL ARTE 20 3.4. OBJETIVO GENERAL 21 OBJETIVOS ESPECÍFICOS 21 3.5. METODOLOGIA PROPUESTA 21 Búsqueda de la literatura 22 Selección de los estudios 22 3.6. PREGUNTAS DE INVESTIGACIÓN 22 ¿Cuál es la eficacia y riesgo de los antidepresivos (NO ADT) para el manejo de la depresión del adulto mayor en comparación con placebo? 22 ¿La eficacia y riesgo del uso de los antidepresivos en la población adulta mayor difiere según su mecanismo de acción? 23 ¿Cuáles son los factores que influyen en la presencia de efectos adversos graves al administrar un tratamiento antidepresivo en un adulto mayor con depresión? 23 ¿Existen diferencias en el tiempo de respuesta o remisión antidepresiva entre la población adulta mayor y población adulta joven con depresión mayor? 24 ¿En pacientes adultos mayores con depresión mayor usando antidepresivos, cuales son los factores que influyen en una recaída o recurrencia de la enfermedad? 24 4. RESULTADOS 25 4.1. ¿Cuál es la eficacia y riesgo de los antidepresivos (NO ADT) para el manejo de la depresión del adulto mayor en comparación con placebo? 25 Metodología para la búsqueda de la literatura 25 Gráfica Flujograma PRISMA 28 Resultados de la búsqueda 29 4.1.3.1. Pacientes sin deterioro cognitivo 29 Respuesta y remisión antidepresiva 29 Recaída depresión en adultos mayores sin deterioro cognitivo 30 Fractura 31 Sangrado Gastrointestinal 32 Hiponatremia 33 Suicidio 34 Muerte 35 Tabla Resumen GRADE 38 Discusión 39 Recomendaciones 40 4.1.3.2. Subgrupo: Pacientes con deterioro cognitivo 45 Respuesta y remisión antidepresiva 45 Recaída 45 Efectos adversos 46 Fractura 47 Suicidio 48 Muerte 49 Tabla Resumen GRADE 51 Discusión 51 Recomendaciones 52 4.2. ¿La eficacia y riesgo del uso de los antidepresivos en la población adulta mayor difiere según su mecanismo de acción? 57 Metodología para la búsqueda de la literatura 57 Gráfica Flujograma PRISMA 58 Resultados de la búsqueda 58 4.2.3.1. Pacientes sin deterioro cognitivo 58 Respuesta y remisión antidepresiva 58 Recaída depresión en adultos mayores sin deterioro cognitivo 60 Efectos adversos 60 Fractura 61 Muerte 61 Hiponatremia 63 Sangrado Gastro intestinal 64 Tablas de resumen GRADE 66 Discusión 70 Recomendación 71 4.2.3.2. Subgrupo: Pacientes con deterioro cognitivo 71 Tabla Resumen GRADE 72 Discusión 72 Recomendaciones 73 4.3. ¿Cuáles son los factores que influyen en la presencia de efectos adversos graves al administrar un tratamiento antidepresivo en un adulto mayor con depresión? 73 Metodología para la búsqueda de la literatura 73 Gráfica Flujograma PRISMA 74 Resultados 74 Fracturas 74 Sangrado Gastrointestinal 77 Hiponatremia 78 Suicidio 79 Muerte 81 Tabla resumen GRADE 83 Discusión 83 Recomendación 85 4.4. ¿Existen diferencias en el tiempo de respuesta o remisión antidepresiva entre la población adulta mayor y población adulta joven con depresión mayor? 86 Metodología para la búsqueda de la literatura 86 Grafica flujograma PRISMA 88 Resultados de la búsqueda 88 Discusión 89 Recomendación 90 4.5. ¿En pacientes adultos mayores con depresión mayor usando antidepresivos, cuales son los factores que influyen en una recaída o recurrencia de la enfermedad? 90 Metodología para la búsqueda de la literatura 90 Grafica flujograma PRISMA 91 Resultados de la búsqueda 91 Discusión 92 Recomendación 93 5. LIMITACIONES 94 6. MODIFICACIONES AL PROTOCOLO 95 7. APÉNDICE 96 8. BIBLIOGRAFÍA 97
dc.description	Maestría
dc.description	Depression in the elderly is a pathology with high prevalence and complications in a population group in constant growth which entails multiple challenges due to the influence of various biopsychosocial factors that are not present in other population groups. It is associated with a worse prognosis, chronic course, lower antidepressant response and higher risk of relapse or recurrence. The use of antidepressant drugs in the elderly has been correlated with significant adverse effects that could be life-threatening and that must be taken into account when planning treatment. The information that currently exists in guidelines on antidepressant drug treatment is focused on the general population, is not based on evidence or is not synthesized. These present guidelines allow information to be transmitted in a clear, synthesized way, thus health professionals are able to make therapeutic decisions more quickly, avoid complications, prevent inappropriate use of drugs, and improve treatment guidelines for the benefit of the elderly.
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dc.language	spa
dc.publisher	Universidad Autónoma de Bucaramanga UNAB
dc.publisher	Facultad Ciencias de la Salud
dc.publisher	Maestría en Métodos para la Producción y Aplicación de Conocimiento Científico en Salud
dc.relation	Agüera-Ortiz, L., Claver-Martín, M. D., Franco-Fernández, M. D., López-Álvarez, J., Martín-Carrasco, M., Ramos-García, M. I., & Sánchez-Pérez, M. (2020). Depression in the Elderly. Consensus Statement of the Spanish Psychogeriatric Association. Frontiers in Psychiatry, 11. https://doi.org/10.3389/fpsyt.2020.00380
dc.relation	Alhawassi, T. M., Alatawi, W., & Alwhaibi, M. (2019). Prevalence of potentially inappropriate medications use among older adults and risk factors using the 2015 American Geriatrics Society Beers criteria. BMC Geriatrics, 19(1), 154. https://doi.org/10.1186/s12877-019 1168-1
dc.relation	Allard, P., Gram, L., Timdahl, K., Behnke, K., Hanson, M., & Søgaard, J. (2004). Efficacy and tolerability of venlafaxine in geriatric outpatients with major depression: A double-blind, randomised 6-month comparative trial with citalopram. International Journal of Geriatric Psychiatry, 19(12), 1123-1130. https://doi.org/10.1002/gps.1190
dc.relation	Almeida, O. P., Alfonso, H., Hankey, G. J., & Flicker, L. (2010). Depression, antidepressant use and mortality in later life: The Health In Men Study. PloS One, 5(6), e11266. https://doi.org/10.1371/journal.pone.0011266
dc.relation	American Psychological Association (APA). (2019). Clinical Practice Guideline for the Treatment of Depression Across Three Age Cohorts American Psychological Association Guideline Development Panel for the Treatment of Depressive Disorders
dc.relation	Anglin, R., Yuan, Y., Moayyedi, P., Tse, F., Armstrong, D., & Leontiadis, G. I. (2014). Risk of upper gastrointestinal bleeding with selective serotonin reuptake inhibitors with or without concurrent nonsteroidal anti-inflammatory use: A systematic review and meta-analysis. The American Journal of Gastroenterology, 109(6), 811-819. https://doi.org/10.1038/ajg.2014.82
dc.relation	Artigas, F. (2013). Serotonin receptors involved in antidepressant effects. Pharmacology & Therapeutics, 137(1), 119-131. https://doi.org/10.1016/j.pharmthera.2012.09.006
dc.relation	Avasthi, A., & Grover, S. (2018). Clinical Practice Guidelines for Management of Depression in Elderly. Indian Journal of Psychiatry, 60(Suppl 3), S341-S362. https://doi.org/10.4103/0019-5545.224474
dc.relation	Bains, J., Birks, J., & Dening, T. (2002). Antidepressants for treating depression in dementia. The Cochrane Database of Systematic Reviews, 4, CD003944. https://doi.org/10.1002/14651858.CD003944
dc.relation	Bajbouj, M., & Danker-Hopfe, H. (2006). Maintenance treatment of depression in old age. The New England Journal of Medicine, 354(23), 2505-2506; author reply 2505-2506
dc.relation	Bakken, M. S., Engeland, A., Engesæter, L. B., Ranhoff, A. H., Hunskaar, S., & Ruths, S. (2013). Increased risk of hip fracture among older people using antidepressant drugs: Data from the Norwegian Prescription Database and the Norwegian Hip Fracture Registry. Age and Ageing, 42(4), 514-520. https://doi.org/10.1093/ageing/aft009
dc.relation	Banerjee, S., Hellier, J., Dewey, M., Romeo, R., Ballard, C., Baldwin, R., Bentham, P., Fox, C., Holmes, C., Katona, C., Knapp, M., Lawton, C., Lindesay, J., Livingston, G., McCrae, N., Moniz-Cook, E., Murray, J., Nurock, S., Orrell, M., … Burns, A. (2011). Sertraline or mirtazapine for depression in dementia (HTA-SADD): A randomised, multicentre, double blind, placebo-controlled trial. Lancet (London, England), 378(9789), 403-411. https://doi.org/10.1016/S0140-6736(11)60830-1
dc.relation	Barbui, C., Esposito, E., & Cipriani, A. (2009). Selective serotonin reuptake inhibitors and risk of suicide: A systematic review of observational studies. CMAJ: Canadian Medical Association Journal = Journal de l’Association Medicale Canadienne, 180(3), 291-297. https://doi.org/10.1503/cmaj.081514
dc.relation	Bobo, W. V., Grossardt, B. R., Lapid, M. I., Leung, J. G., Stoppel, C., Takahashi, P. Y., Hoel, R. W., Chang, Z., Lachner, C., Chauhan, M., Flowers, L., Brue, S. M., Frye, M. A., St Sauver, J., Rocca, W. A., & Sutor, B. (2019). Frequency and predictors of the potential overprescribing of antidepressants in elderly residents of a geographically defined U.S. population. Pharmacology Research & Perspectives, 7(1), e00461. https://doi.org/10.1002/prp2.461
dc.relation	Boström, G., Hörnsten, C., Brännström, J., Conradsson, M., Nordström, P., Allard, P., Gustafson, Y., & Littbrand, H. (2016). Antidepressant use and mortality in very old people. International Psychogeriatrics, 28(7), 1201-1210. https://doi.org/10.1017/S104161021600048X
dc.relation	Brännström, J., Lövheim, H., Gustafson, Y., & Nordström, P. (2019). Association Between Antidepressant Drug Use and Hip Fracture in Older People Before and After Treatment Initiation. JAMA Psychiatry, 76(2), 172. https://doi.org/10.1001/jamapsychiatry.2018.3679
dc.relation	Brzezińska, A., Bourke, J., Rivera-Hernández, R., Tsolaki, M., Woźniak, J., & Kaźmierski, J. (2020). Depression in Dementia or Dementia in Depression? Systematic Review of Studies and Hypotheses. Current Alzheimer Research, 17(1), 16-28. https://doi.org/10.2174/1567205017666200217104114
dc.relation	By the 2019 American Geriatrics Society Beers Criteria® Update Expert Panel. (2019). American Geriatrics Society 2019 Updated AGS Beers Criteria® for Potentially Inappropriate Medication Use in Older Adults. Journal of the American Geriatrics Society, 67(4), 674-694. https://doi.org/10.1111/jgs.15767
dc.relation	Censo Nacional de Población y Vivienda 2018. (s. f.). Recuperado 5 de octubre de 2020, de https://www.dane.gov.co/index.php/estadisticas-por-tema/demografia-y poblacion/censo-nacional-de-poblacion-y-vivenda-2018
dc.relation	Cheng, Y.-L., Hu, H.-Y., Lin, X.-H., Luo, J.-C., Peng, Y.-L., Hou, M.-C., Lin, H.-C., & Lee, F.-Y. (2015). Use of SSRI, But Not SNRI, Increased Upper and Lower Gastrointestinal Bleeding. Medicine, 94(46). https://doi.org/10.1097/MD.0000000000002022
dc.relation	Choi, J. W., Lee, K. S., & Han, E. (2021). Suicide risk within 1 year of dementia diagnosis in older adults: A nationwide retrospective cohort study. Journal of Psychiatry & Neuroscience: JPN, 46(1), E119-E127. https://doi.org/10.1503/jpn.190219
dc.relation	Cipriani, A., Furukawa, T. A., Salanti, G., Chaimani, A., Atkinson, L. Z., Ogawa, Y., Leucht, S., Ruhe, H. G., Turner, E. H., Higgins, J. P. T., Egger, M., Takeshima, N., Hayasaka, Y., Imai, H., Shinohara, K., Tajika, A., Ioannidis, J. P. A., & Geddes, J. R. (2018). Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: A systematic review and network meta-analysis. Lancet (London, England), 391(10128), 1357-1366. https://doi.org/10.1016/S0140-6736(17)32802-7
dc.relation	Corona, G., Giuliani, C., Parenti, G., Colombo, G. L., Sforza, A., Maggi, M., Forti, G., & Peri, A. (2016). The Economic Burden of Hyponatremia: Systematic Review and Meta-Analysis. The American Journal of Medicine, 129(8), 823-835.e4. https://doi.org/10.1016/j.amjmed.2016.03.007
dc.relation	Corona, G., Norello, D., Parenti, G., Sforza, A., Maggi, M., & Peri, A. (2018). Hyponatremia, falls and bone fractures: A systematic review and meta-analysis. Clinical Endocrinology, 89(4), 505 513. https://doi.org/10.1111/cen.13790
dc.relation	Coupland, C., Dhiman, P., Morriss, R., Arthur, A., Barton, G., & Hippisley-Cox, J. (2011). Antidepressant use and risk of adverse outcomes in older people: Population based cohort study. BMJ (Clinical Research Ed.), 343, d4551. https://doi.org/10.1136/bmj.d4551
dc.relation	Davies, L. E., Spiers, G., Kingston, A., Todd, A., Adamson, J., & Hanratty, B. (2020). Adverse Outcomes of Polypharmacy in Older People: Systematic Review of Reviews. Journal of the 101 American Medical Directors Association, 21(2), 181-187. https://doi.org/10.1016/j.jamda.2019.10.022
dc.relation	de Vasconcelos Cunha, U. G., Lopes Rocha, F., Avila de Melo, R., Alves Valle, E., de Souza Neto, J. J., Mendes Brega, R., Magalhães Scoralick, F., Araújo Silva, S., Martins de Oliveira, F., da Costa Júnior, A. L., Faria Alves, V. X., & Sakurai, E. (2007). A placebo-controlled double-blind randomized study of venlafaxine in the treatment of depression in dementia. Dementia and Geriatric Cognitive Disorders, 24(1), 36-41. https://doi.org/10.1159/000102570
dc.relation	Diem, S. J., Blackwell, T. L., Stone, K. L., Cauley, J. A., Hillier, T. A., Haney, E. M., & Ensrud, K. E. (2011). Use of Antidepressant Medications and Risk of Fracture in Older Women. Calcified tissue international, 88(6), 476-484. https://doi.org/10.1007/s00223-011-9481-5
dc.relation	Driscoll, H. C., Basinski, J., Mulsant, B. H., Butters, M. A., Dew, M. A., Houck, P. R., Mazumdar, S., Miller, M. D., Pollock, B. G., Stack, J. A., Schlernitzauer, M. A., & Reynolds, C. F. (2005). Late-onset major depression: Clinical and treatment-response variability. International Journal of Geriatric Psychiatry, 20(7), 661-667. https://doi.org/10.1002/gps.1334
dc.relation	Du, Y., Wolf, I.-K., Busch, M. A., & Knopf, H. (2019). Associations between the use of specific psychotropic drugs and all-cause mortality among older adults in Germany: Results of the mortality follow-up of the German National Health Interview and Examination Survey 1998. PloS One, 14(1), e0210695. https://doi.org/10.1371/journal.pone.0210695
dc.relation	Dudas, R., Malouf, R., McCleery, J., & Dening, T. (2018). Antidepressants for treating depression in dementia. The Cochrane Database of Systematic Reviews, 8, CD003944. https://doi.org/10.1002/14651858.CD003944.pub2
dc.relation	Emeny, R. T., Chang, C.-H., Skinner, J., O’Malley, A. J., Smith, J., Chakraborti, G., Rosen, C. J., & Morden, N. E. (2019). Association of Receiving Multiple, Concurrent Fracture-Associated 102 Drugs With Hip Fracture Risk. JAMA Network Open, 2(11), e1915348. https://doi.org/10.1001/jamanetworkopen.2019.15348
dc.relation	Enache, D., Fereshtehnejad, S.-M., Kåreholt, I., Cermakova, P., Garcia-Ptacek, S., Johnell, K., Religa, D., Jelic, V., Winblad, B., Ballard, C., Aarsland, D., Fastbom, J., & Eriksdotter, M. (2016). Antidepressants and mortality risk in a dementia cohort: Data from SveDem, the Swedish Dementia Registry. Acta Psychiatrica Scandinavica, 134(5), 430-440. https://doi.org/10.1111/acps.12630
dc.relation	Eom, C.-S., Lee, H.-K., Ye, S., Park, S. M., & Cho, K.-H. (2012). Use of selective serotonin reuptake inhibitors and risk of fracture: A systematic review and meta-analysis. Journal of Bone and Mineral Research: The Official Journal of the American Society for Bone and Mineral Research, 27(5), 1186-1195. https://doi.org/10.1002/jbmr.1554
dc.relation	Fabian, T. J., Amico, J. A., Kroboth, P. D., Mulsant, B. H., Corey, S. E., Begley, A. E., Bensasi, S. G., Weber, E., Dew, M. A., Reynolds, C. F., & Pollock, B. G. (2004). Paroxetine-induced hyponatremia in older adults: A 12-week prospective study. Archives of Internal Medicine, 164(3), 327-332. https://doi.org/10.1001/archinte.164.3.327
dc.relation	Farmand, S., Lindh, J. D., Calissendorff, J., Skov, J., Falhammar, H., Nathanson, D., & Mannheimer, B. (2018). Differences in Associations of Antidepressants and Hospitalization Due to Hyponatremia. The American Journal of Medicine, 131(1), 56-63. https://doi.org/10.1016/j.amjmed.2017.07.025
dc.relation	Fergusson, D., Doucette, S., Glass, K. C., Shapiro, S., Healy, D., Hebert, P., & Hutton, B. (2005). Association between suicide attempts and selective serotonin reuptake inhibitors: Systematic review of randomised controlled trials. BMJ : British Medical Journal, 330(7488), 396
dc.relation	Furukawa, T. A., Cipriani, A., Cowen, P. J., Leucht, S., Egger, M., & Salanti, G. (2019). Optimal dose of selective serotonin reuptake inhibitors, venlafaxine, and mirtazapine in major depression: A systematic review and dose-response meta-analysis. The Lancet. Psychiatry, 6(7), 601-609. https://doi.org/10.1016/S2215-0366(19)30217-2
dc.relation	Gandhi, S., Shariff, S. Z., Al-Jaishi, A., Reiss, J. P., Mamdani, M. M., Hackam, D. G., Li, L., McArthur, E., Weir, M. A., & Garg, A. X. (2017). Second-Generation Antidepressants and Hyponatremia Risk: A Population-Based Cohort Study of Older Adults. American Journal of Kidney Diseases: The Official Journal of the National Kidney Foundation, 69(1), 87-96. https://doi.org/10.1053/j.ajkd.2016.08.020
dc.relation	González Quiñones, J. C. (2017). Resumen: «Sabe Colombia 2015: Estudio Nacional de Salud, Bienestar y Envejecimiento». Carta Comunitaria, 25(144), 24.
dc.relation	Gorwood, P., Weiller, E., Lemming, O., & Katona, C. (2007). Escitalopram prevents relapse in older patients with major depressive disorder. The American Journal of Geriatric Psychiatry: Official Journal of the American Association for Geriatric Psychiatry, 15(7), 581-593. https://doi.org/10.1097/01.JGP.0000240823.94522.4c
dc.relation	Gøtzsche, P. C., & Dinnage, O. (2020). What have antidepressants been tested for? A systematic review. The International Journal of Risk & Safety in Medicine, 31(3), 157-163. https://doi.org/10.3233/JRS-200006
dc.relation	Grayson, L., & Thomas, A. (2013). A systematic review comparing clinical features in early age at onset and late age at onset late-life depression. Journal of Affective Disorders, 150(2), 161 170. https://doi.org/10.1016/j.jad.2013.03.021
dc.relation	Gutiérrez-Rojas, L., Porras-Segovia, A., Dunne, H., Andrade-González, N., & Cervilla, J. A. (2020). Prevalence and correlates of major depressive disorder: A systematic review. Revista Brasileira De Psiquiatria (Sao Paulo, Brazil: 1999). https://doi.org/10.1590/1516-4446 2020-0650
dc.relation	Hedna, K., Andersson Sundell, K., Hensing, G., Skoog, I., Gustavsson, S., & Waern, M. (2018). Late life suicidal behaviours among new users of antidepressants: A prospective population based study of sociodemographic and gender factors in those aged 75 and above. BMJ Open, 8(10). https://doi.org/10.1136/bmjopen-2018-022703
dc.relation	Hedna, K., Hensing, G., Skoog, I., Fastbom, J., & Waern, M. (2020). Sociodemographic and gender determinants of late-life suicide in users and non-users of antidepressants. The European Journal of Public Health, 30(5), 958-964. https://doi.org/10.1093/eurpub/ckaa114
dc.relation	Hedrick, R., Korouri, S., Tadros, E., Darwish, T., Cortez, V., Triay, D., Pasini, M., Olanisa, L., Herrera, N., Hanna, S., Kimchi, A., Hamilton, M., Danovitch, I., & IsHak, W. W. (2020). The impact of antidepressants on depressive symptom severity, quality of life, morbidity, and mortality in heart failure: A systematic review. Drugs in Context, 9. https://doi.org/10.7573/dic.2020-5-4
dc.relation	Hegeman, J. M., Kok, R. M., Mast, R. C. van der, & Giltay, E. J. (2012). Phenomenology of depression in older compared with younger adults: Meta-analysis. The British Journal of Psychiatry, 200(4), 275-281. https://doi.org/10.1192/bjp.bp.111.095950
dc.relation	Hengartner, M. P., Amendola, S., Kaminski, J. A., Kindler, S., Bschor, T., & Plöderl, M. (2020). Suicide risk with selective serotonin reuptake inhibitors and new-generation serotonergic noradrenergic antidepressants in adults: A systematic review and meta-analysis of observational studies. MedRxiv, 2020.05.11.20098178. https://doi.org/10.1101/2020.05.11.20098178
dc.relation	Henssler, J., Kurschus, M., Franklin, J., Bschor, T., & Baethge, C. (2018). Trajectories of Acute Antidepressant Efficacy: How Long to Wait for Response? A Systematic Review and Meta 105 Analysis of Long-Term, Placebo-Controlled Acute Treatment Trials. The Journal of Clinical Psychiatry, 79(3). https://doi.org/10.4088/JCP.17r11470
dc.relation	Jeuring, H. W., Stek, M. L., Huisman, M., Oude Voshaar, R. C., Naarding, P., Collard, R. M., van der Mast, R. C., Kok, R. M., Beekman, A. T. F., & Comijs, H. C. (2018). A Six-Year Prospective Study of the Prognosis and Predictors in Patients With Late-Life Depression. The American Journal of Geriatric Psychiatry: Official Journal of the American Association for Geriatric Psychiatry, 26(9), 985-997. https://doi.org/10.1016/j.jagp.2018.05.005
dc.relation	Jiang, H.-Y., Chen, H.-Z., Hu, X.-J., Yu, Z.-H., Yang, W., Deng, M., Zhang, Y.-H., & Ruan, B. (2015). Use of selective serotonin reuptake inhibitors and risk of upper gastrointestinal bleeding: A systematic review and meta-analysis. Clinical Gastroenterology and Hepatology: The Official Clinical Practice Journal of the American Gastroenterological Association, 13(1), 42 50.e3. https://doi.org/10.1016/j.cgh.2014.06.021
dc.relation	Kasper, S., de Swart, H., & Friis Andersen, H. (2005). Escitalopram in the treatment of depressed elderly patients. The American Journal of Geriatric Psychiatry: Official Journal of the American Association for Geriatric Psychiatry, 13(10), 884-891. https://doi.org/10.1176/appi.ajgp.13.10.884
dc.relation	Katona, C., Hansen, T., & Olsen, C. K. (2012). A randomized, double-blind, placebo-controlled, duloxetine-referenced, fixed-dose study comparing the efficacy and safety of Lu AA21004 in elderly patients with major depressive disorder: International Clinical Psychopharmacology, 27(4), 215-223. https://doi.org/10.1097/YIC.0b013e3283542457
dc.relation	Khanassov, V., Hu, J., Reeves, D., & van Marwijk, H. (2018). Selective serotonin reuptake inhibitor and selective serotonin and norepinephrine reuptake inhibitor use and risk of fractures in adults: A systematic review and meta-analysis. International Journal of Geriatric Psychiatry, 33(12), 1688-1708. https://doi.org/10.1002/gps.4974
dc.relation	Klysner, R., Bent-Hansen, J., Hansen, H. L., Lunde, M., Pleidrup, E., Poulsen, D. L., Andersen, M., & Petersen, H. E. H. (2002). Efficacy of citalopram in the prevention of recurrent depression in elderly patients: Placebo-controlled study of maintenance therapy. The British Journal of Psychiatry: The Journal of Mental Science, 181, 29-35. https://doi.org/10.1192/bjp.181.1.29
dc.relation	Kok, R. M., Nolen, W. A., & Heeren, T. J. (2012). Efficacy of treatment in older depressed patients: A systematic review and meta-analysis of double-blind randomized controlled trials with antidepressants. Journal of Affective Disorders, 141(2-3), 103-115. https://doi.org/10.1016/j.jad.2012.02.036
dc.relation	KoKoAung, E., Cavenett, S., McArthur, A., & Aromataris, E. (2015). The association between suicidality and treatment with selective serotonin reuptake inhibitors in older people with major depression: A systematic review. JBI Database of Systematic Reviews and Implementation Reports, 13(3), 174-205. https://doi.org/10.11124/jbisrir-2015-2272
dc.relation	Kollhorst, B., Jobski, K., Krappweis, J., Schink, T., Garbe, E., & Schmedt, N. (2019). Antidepressants and the risk of death in older patients with depression: A population-based cohort study. PLOS ONE, 14(4), e0215289. https://doi.org/10.1371/journal.pone.0215289
dc.relation	Krause, M., Gutsmiedl, K., Bighelli, I., Schneider-Thoma, J., Chaimani, A., & Leucht, S. (2019). Efficacy and tolerability of pharmacological and non-pharmacological interventions in older patients with major depressive disorder: A systematic review, pairwise and network meta-analysis. European Neuropsychopharmacology: The Journal of the European College of Neuropsychopharmacology, 29(9), 1003-1022. https://doi.org/10.1016/j.euroneuro.2019.07.130
dc.relation	Kumar, M., Bajpai, R., Shaik, A. R., Srivastava, S., & Vohora, D. (2020). Alliance between selective serotonin reuptake inhibitors and fracture risk: An updated systematic review and meta 107 analysis. European Journal of Clinical Pharmacology, 76(10), 1373-1392. https://doi.org/10.1007/s00228-020-02893-1
dc.relation	Kuring, J. K., Mathias, J. L., & Ward, L. (2018). Prevalence of Depression, Anxiety and PTSD in People with Dementia: A Systematic Review and Meta-Analysis. Neuropsychology Review, 28(4), 393-416. https://doi.org/10.1007/s11065-018-9396-2
dc.relation	Lam, R. W., Kennedy, S. H., Grigoriadis, S., McIntyre, R. S., Milev, R., Ramasubbu, R., Parikh, S. V., Patten, S. B., & Ravindran, A. V. (2009). Canadian Network for Mood and Anxiety Treatments (CANMAT) Clinical guidelines for the management of major depressive disorder in adults.: III. Pharmacotherapy. Journal of Affective Disorders, 117, S26-S43. https://doi.org/10.1016/j.jad.2009.06.041
dc.relation	Lanteigne, A., Sheu, Y., Stürmer, T., Pate, V., Azrael, D., Swanson, S. A., & Miller, M. (2015). Serotonin-Norepinephrine Reuptake Inhibitor and Selective Serotonin Reuptake Inhibitor Use and Risk of Fractures: A new-user cohort study among US adults aged 50 and older. CNS drugs, 29(3), 245-252. https://doi.org/10.1007/s40263-015-0231-5
dc.relation	Leach, M. J., Pratt, N. L., & Roughead, E. E. (2017). Risk of Hip Fracture in Older People Using Selective Serotonin Reuptake Inhibitors and Other Psychoactive Medicines Concurrently: A Matched Case-Control Study in Australia. Drugs - Real World Outcomes, 4(2), 87-96. https://doi.org/10.1007/s40801-017-0107-8
dc.relation	Leipzig, R. M., Cumming, R. G., & Tinetti, M. E. (1999). Drugs and falls in older people: A systematic review and meta-analysis: I. Psychotropic drugs. Journal of the American Geriatrics Society, 47(1), 30-39. https://doi.org/10.1111/j.1532-5415.1999.tb01898.x
dc.relation	eth-Møller, K. B., Hansen, A. H., Torstensson, M., Andersen, S. E., Ødum, L., Gislasson, G., Torp Pedersen, C., & Holm, E. A. (2016). Antidepressants and the risk of hyponatremia: A Danish 108 register-based population study. BMJ Open, 6(5), e011200. https://doi.org/10.1136/bmjopen-2016-011200
dc.relation	Li, J.-Q., Tan, L., Wang, H.-F., Tan, M.-S., Tan, L., Xu, W., Zhao, Q.-F., Wang, J., Jiang, T., & Yu, J.-T. (2016). Risk factors for predicting progression from mild cognitive impairment to Alzheimer’s disease: A systematic review and meta-analysis of cohort studies. Journal of Neurology, Neurosurgery, and Psychiatry, 87(5), 476-484. https://doi.org/10.1136/jnnp 2014-310095
dc.relation	Licht-Strunk, E., van der Windt, D. A., van Marwijk, H. W., de Haan, M., & Beekman, A. T. (2007). The prognosis of depression in older patients in general practice and the community. A systematic review. Family Practice, 24(2), 168-180. https://doi.org/10.1093/fampra/cml071
dc.relation	Livingston, G., Huntley, J., Sommerlad, A., Ames, D., Ballard, C., Banerjee, S., Brayne, C., Burns, A., Cohen-Mansfield, J., Cooper, C., Costafreda, S. G., Dias, A., Fox, N., Gitlin, L. N., Howard, R., Kales, H. C., Kivimäki, M., Larson, E. B., Ogunniyi, A., … Mukadam, N. (2020). Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. The Lancet, 396(10248), 413-446. https://doi.org/10.1016/S0140-6736(20)30367-6
dc.relation	Loke, Y. K., Trivedi, A. N., & Singh, S. (2007). Meta-analysis: Gastrointestinal bleeding due to interaction between selective serotonin uptake inhibitors and non-steroidal anti inflammatory drugs: META-ANALYSIS: GASTROINTESTINAL BLEEDING WITH SSRIS AND NSAID. Alimentary Pharmacology & Therapeutics, 27(1), 31-40. https://doi.org/10.1111/j.1365-2036.2007.03541.x
dc.relation	Lombardi, G., Ferraro, P. M., Calvaruso, L., Naticchia, A., D’Alonzo, S., & Gambaro, G. (2019). Sodium Fluctuations and Mortality in a General Hospitalized Population. Kidney & Blood Pressure Research, 44(4), 604-614. https://doi.org/10.1159/000500916
dc.relation	Luppa, M., Sikorski, C., Luck, T., Ehreke, L., Konnopka, A., Wiese, B., Weyerer, S., König, H.-H., & Riedel-Heller, S. G. (2012). Age- and gender-specific prevalence of depression in latest life—Systematic review and meta-analysis. Journal of Affective Disorders, 136(3), 212-221. https://doi.org/10.1016/j.jad.2010.11.033
dc.relation	Luzecky, M. H., Burman, K. D., & Schultz, E. R. (1974). The syndrome of inappropriate secretion of antidiuretic hormone associated with amitriptyline administration. Southern Medical Journal, 67(4), 495-497. https://doi.org/10.1097/00007611-197404000-00027
dc.relation	Lyketsos, C. G., DelCampo, L., Steinberg, M., Miles, Q., Steele, C. D., Munro, C., Baker, A. S., Sheppard, J.-M. E., Frangakis, C., Brandt, J., & Rabins, P. V. (2003). Treating depression in Alzheimer disease: Efficacy and safety of sertraline therapy, and the benefits of depression reduction: the DIADS. Archives of General Psychiatry, 60(7), 737-746. https://doi.org/10.1001/archpsyc.60.7.737
dc.relation	Mahar, I., Bambico, F. R., Mechawar, N., & Nobrega, J. N. (2014). Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects. Neuroscience and Biobehavioral Reviews, 38, 173-192. https://doi.org/10.1016/j.neubiorev.2013.11.009
dc.relation	Mallery, L., MacLeod, T., Allen, M., McLean-Veysey, P., Rodney-Cail, N., Bezanson, E., Steeves, B., LeBlanc, C., & Moorhouse, P. (2019). Systematic review and meta-analysis of second generation antidepressants for the treatment of older adults with depression: Questionable benefit and considerations for frailty. BMC Geriatrics, 19(1), 306. https://doi.org/10.1186/s12877-019-1327-4
dc.relation	Mannesse, C. K., Vondeling, A. M., van Marum, R. J., van Solinge, W. W., Egberts, T. C. G., & Jansen, P. A. F. (2013). Prevalence of hyponatremia on geriatric wards compared to other 110 settings over four decades: A systematic review. Ageing Research Reviews, 12(1), 165-173. https://doi.org/10.1016/j.arr.2012.04.006
dc.relation	Ministerio de Salud y Protección Social - Colciencias. (2013). Guía de práctica clínica Detección temprana y diagnóstico del episodio depresivo y trastorno depresivo recurrente en adultos. Atención integral de los adultos con diagnóstico de episodio depresivo o trastorno depresivo recurrente. https://medicosgeneralescolombianos.com/images/Guias_2013/gpc_22prof_sal_depre.p df
dc.relation	Mitchell, A. J., & Subramaniam, H. (2005). Prognosis of depression in old age compared to middle age: A systematic review of comparative studies. The American Journal of Psychiatry, 162(9), 1588-1601. https://doi.org/10.1176/appi.ajp.162.9.1588
dc.relation	Mottram, P., Wilson, K., & Strobl, J. (2006). Antidepressants for depressed elderly. The Cochrane Database of Systematic Reviews, 1, CD003491. https://doi.org/10.1002/14651858.CD003491.pub2
dc.relation	Movig, K. L. L., Leufkens, H. G. M., Lenderink, A. W., & Egberts, A. C. G. (2002). Serotonergic antidepressants associated with an increased risk for hyponatraemia in the elderly. European Journal of Clinical Pharmacology, 58(2), 143-148. https://doi.org/10.1007/s00228-002-0438-5
dc.relation	Mukai, Y., & Tampi, R. R. (2009). Treatment of depression in the elderly: A review of the recent literature on the efficacy of single- versus dual-action antidepressants. Clinical Therapeutics, 31(5), 945-961. https://doi.org/10.1016/j.clinthera.2009.05.016
dc.relation	Murthy, K., Ondrey, G. J., Malkani, N., Raman, G., Hodge, M. B., Marcantonio, A. J., & Verbalis, J. G. (2019). THE EFFECTS OF HYPONATREMIA ON BONE DENSITY AND FRACTURES: A SYSTEMATIC REVIEW AND META-ANALYSIS. Endocrine Practice: Official Journal of the 111 American College of Endocrinology and the American Association of Clinical Endocrinologists, 25(4), 366-378. https://doi.org/10.4158/EP-2018-0499
dc.relation	Nelson, J. C., Delucchi, K., & Schneider, L. S. (2008a). Efficacy of second generation antidepressants in late-life depression: A meta-analysis of the evidence. The American Journal of Geriatric Psychiatry: Official Journal of the American Association for Geriatric Psychiatry, 16(7), 558 567. https://doi.org/10.1097/JGP.0b013e3181693288
dc.relation	Nelson, J. C., Delucchi, K., & Schneider, L. S. (2008b). Efficacy of Second Generation Antidepressants in Late-Life Depression: A Meta-Analysis of the Evidence. The American Journal of Geriatric Psychiatry, 16(7), 558-567. https://doi.org/10.1097/01.JGP.0000308883.64832.ed
dc.relation	Nelson, J. C., & Devanand, D. P. (2011). A systematic review and meta-analysis of placebo controlled antidepressant studies in people with depression and dementia. Journal of the American Geriatrics Society, 59(4), 577-585. https://doi.org/10.1111/j.1532 5415.2011.03355.x
dc.relation	Nervenheilkunde (DGPPN), D. G. F. P., Psychotherapie Und, & Ärztliches Zentrum Für Qualität In Der Medizin (ÄZQ). (2015). S3-Leitlinie/Nationale VersorgungsLeitlinie Unipolare Depression—Langfassung, 2. Auflage [Text/pdf]. Deutsche Gesellschaft für Psychiatrie, Psychotherapie und Nervenheilkunde (DGPPN); Bundesärztekammer (BÄK); Kassenärztliche Bundesvereinigung (KBV); Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF). https://doi.org/10.6101/AZQ/000364
dc.relation	Oderda, L. H., Young, J. R., Asche, C. V., & Pepper, G. A. (2012). Psychotropic-related hip fractures: Meta-analysis of first-generation and second-generation antidepressant and antipsychotic drugs. The Annals of Pharmacotherapy, 46(7-8), 917-928. https://doi.org/10.1345/aph.1Q589
dc.relation	Oka, Y., Okamoto, K., Kawashita, N., Shirakuni, Y., & Takagi, T. (2014). Meta-analysis of the Risk of Upper Gastrointestinal Hemorrhage with Combination Therapy of Selective Serotonin Reuptake Inhibitors and Non-steroidal Anti-inflammatory Drugs. Biological and Pharmaceutical Bulletin, 37(6), 947-953. https://doi.org/10.1248/bpb.b13-00885
dc.relation	O’Mahony, D., O’Sullivan, D., Byrne, S., O’Connor, M. N., Ryan, C., & Gallagher, P. (2015). STOPP/START criteria for potentially inappropriate prescribing in older people: Version 2. Age and Ageing, 44(2), 213-218. https://doi.org/10.1093/ageing/afu145
dc.relation	Orgeta, V., Tabet, N., Nilforooshan, R., & Howard, R. (2017). Efficacy of Antidepressants for Depression in Alzheimer’s Disease: Systematic Review and Meta-Analysis. Journal of Alzheimer’s Disease: JAD, 58(3), 725-733. https://doi.org/10.3233/JAD-161247
dc.relation	Peeters, C. M. M., Visser, E., Van de Ree, C. L. P., Gosens, T., Den Oudsten, B. L., & De Vries, J. (2016). Quality of life after hip fracture in the elderly: A systematic literature review. Injury, 47(7), 1369-1382. https://doi.org/10.1016/j.injury.2016.04.018
dc.relation	Pohl, P., Nordin, E., Lundquist, A., Bergström, U., & Lundin-Olsson, L. (2014). Community-dwelling older people with an injurious fall are likely to sustain new injurious falls within 5 years—A prospective long-term follow-up study. BMC Geriatrics, 14, 120. https://doi.org/10.1186/1471-2318-14-120
dc.relation	Practice guideline for the treatment of patients with major depressive disorder, third edition Clinical Practice Guidelines. (s. f.). Guideline Central. Recuperado 12 de octubre de 2020, de https://www.guidelinecentral.com/summaries/practice-guideline-for-the-treatment of-patients-with-major-depressive-disorder-third-edition
dc.relation	Prieto-Alhambra, D., Petri, H., Goldenberg, J. S. B., Khong, T. P., Klungel, O. H., Robinson, N. J., & de Vries, F. (2014). Excess risk of hip fractures attributable to the use of antidepressants in five European countries and the USA. Osteoporosis International: A Journal Established as 113 Result of Cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 25(3), 847-855. https://doi.org/10.1007/s00198-013-2612-2
dc.relation	Rabenda, V., Nicolet, D., Beaudart, C., Bruyère, O., & Reginster, J.-Y. (2013). Relationship between use of antidepressants and risk of fractures: A meta-analysis. Osteoporosis International: A Journal Established as Result of Cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 24(1), 121-137. https://doi.org/10.1007/s00198-012-2015-9
dc.relation	Rajeswaran, T., Plymen, C. M., & Doherty, A. M. (2018). The effect of antidepressant medications in the management of heart failure on outcomes: Mortality, cardiovascular function and depression - a systematic review. International Journal of Psychiatry in Clinical Practice, 22(3), 164-169. https://doi.org/10.1080/13651501.2017.1401085
dc.relation	Raskin, J., Wiltse, C. G., Dinkel, J. J., Walker, D. J., Desaiah, D., & Katona, C. (2008). Safety and tolerability of duloxetine at 60 mg once daily in elderly patients with major depressive disorder. Journal of Clinical Psychopharmacology, 28(1), 32-38. https://doi.org/10.1097/jcp.0b013e318160738e
dc.relation	Reynolds, C. F., Dew, M. A., Frank, E., Begley, A. E., Miller, M. D., Cornes, C., Mazumdar, S., Perel, J. M., & Kupfer, D. J. (1998). Effects of age at onset of first lifetime episode of recurrent major depression on treatment response and illness course in elderly patients. The American Journal of Psychiatry, 155(6), 795-799. https://doi.org/10.1176/ajp.155.6.795
dc.relation	Reynolds, Charles F., Dew, M. A., Pollock, B. G., Mulsant, B. H., Frank, E., Miller, M. D., Houck, P. R., Mazumdar, S., Butters, M. A., Stack, J. A., Schlernitzauer, M. A., Whyte, E. M., Gildengers, A., Karp, J., Lenze, E., Szanto, K., Bensasi, S., & Kupfer, D. J. (2006). Maintenance treatment 114 of major depression in old age. The New England Journal of Medicine, 354(11), 1130-1138. https://doi.org/10.1056/NEJMoa052619
dc.relation	Robinson, M., Oakes, T. M., Raskin, J., Liu, P., Shoemaker, S., & Nelson, J. C. (2014). Acute and Long-term Treatment of Late-Life Major Depressive Disorder: Duloxetine Versus Placebo. The American Journal of Geriatric Psychiatry, 22(1), 34-45. https://doi.org/10.1016/j.jagp.2013.01.019
dc.relation	Rosenberg, P. B., Drye, L. T., Martin, B. K., Frangakis, C., Mintzer, J. E., Weintraub, D., Porsteinsson, A. P., Schneider, L. S., Rabins, P. V., Munro, C. A., Meinert, C. L., & Lyketsos, C. G. (2010). Sertraline for the treatment of depression in Alzheimer’s disease. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 18(2), 136-145. https://doi.org/10.1097/JGP.0b013e3181c796eb
dc.relation	Ryan, J., Carriere, I., Ritchie, K., Stewart, R., Toulemonde, G., Dartigues, J.-F., Tzourio, C., & Ancelin, M.-L. (2008). Late-life depression and mortality: Influence of gender and antidepressant use. The British Journal of Psychiatry: The Journal of Mental Science, 192(1), 12-18. https://doi.org/10.1192/bjp.bp.107.039164
dc.relation	Schatzberg, A., & Roose, S. (2006). A double-blind, placebo-controlled study of venlafaxine and fluoxetine in geriatric outpatients with major depression. The American Journal of Geriatric Psychiatry: Official Journal of the American Association for Geriatric Psychiatry, 14(4), 361-370. https://doi.org/10.1097/01.JGP.0000194645.70869.3b
dc.relation	Seitz, D. P., Adunuri, N., Gill, S. S., Gruneir, A., Herrmann, N., & Rochon, P. (2011). Antidepressants for agitation and psychosis in dementia. The Cochrane Database of Systematic Reviews, 2, CD008191. https://doi.org/10.1002/14651858.CD008191.pub2
dc.relation	Seppala, L. J., Wermelink, A. M. A. T., de Vries, M., Ploegmakers, K. J., van de Glind, E. M. M., Daams, J. G., van der Velde, N., & EUGMS task and Finish group on fall-risk-increasing 115 drugs. (2018). Fall-Risk-Increasing Drugs: A Systematic Review and Meta-Analysis: II. Psychotropics. Journal of the American Medical Directors Association, 19(4), 371.e11 371.e17. https://doi.org/10.1016/j.jamda.2017.12.098
dc.relation	Seyfried, L. S., Kales, H. C., Ignacio, R. V., Conwell, Y., & Valenstein, M. (2011). Predictors of suicide in patients with dementia. Alzheimer’s & dementia : the journal of the Alzheimer’s Association, 7(6), 567-573. https://doi.org/10.1016/j.jalz.2011.01.006
dc.relation	Sjöberg, L., Karlsson, B., Atti, A.-R., Skoog, I., Fratiglioni, L., & Wang, H.-X. (2017). Prevalence of depression: Comparisons of different depression definitions in population-based samples of older adults. Journal of Affective Disorders, 221, 123-131. https://doi.org/10.1016/j.jad.2017.06.011
dc.relation	Smith, D., Dempster, C., Glanville, J., Freemantle, N., & Anderson, I. (2002). Efficacy and tolerability of venlafaxine compared with selective serotonin reuptake inhibitors and other antidepressants: A meta-analysis. The British Journal of Psychiatry: The Journal of Mental Science, 180, 396-404. https://doi.org/10.1192/bjp.180.5.396
dc.relation	Tedeschini, E., Levkovitz, Y., Iovieno, N., Ameral, V. E., Nelson, J. C., & Papakostas, G. I. (2011). Efficacy of antidepressants for late-life depression: A meta-analysis and meta-regression of placebo-controlled randomized trials. The Journal of Clinical Psychiatry, 72(12), 1660-1668. https://doi.org/10.4088/JCP.10r06531
dc.relation	Tham, A., Jonsson, U., Andersson, G., Söderlund, A., Allard, P., & Bertilsson, G. (2016a). Efficacy and tolerability of antidepressants in people aged 65 years or older with major depressive disorder—A systematic review and a meta-analysis. Journal of Affective Disorders, 205, 1 12. https://doi.org/10.1016/j.jad.2016.06.013
dc.relation	Tham, A., Jonsson, U., Andersson, G., Söderlund, A., Allard, P., & Bertilsson, G. (2016b). Efficacy and tolerability of antidepressants in people aged 65 years or older with major depressive 116 disorder—A systematic review and a meta-analysis. Journal of Affective Disorders, 205, 1 12. https://doi.org/10.1016/j.jad.2016.06.013
dc.relation	Thompson, S., Herrmann, N., Rapoport, M. J., & Lanctôt, K. L. (2007). Efficacy and safety of antidepressants for treatment of depression in Alzheimer’s disease: A metaanalysis. Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie, 52(4), 248-255. https://doi.org/10.1177/070674370705200407
dc.relation	Thorlund, K., Druyts, E., Wu, P., Balijepalli, C., Keohane, D., & Mills, E. (2015). Comparative efficacy and safety of selective serotonin reuptake inhibitors and serotonin-norepinephrine reuptake inhibitors in older adults: A network meta-analysis. Journal of the American Geriatrics Society, 63(5), 1002-1009. https://doi.org/10.1111/jgs.13395
dc.relation	Torvinen-Kiiskinen, S., Tolppanen, A.-M., Koponen, M., Tanskanen, A., Tiihonen, J., Hartikainen, S., & Taipale, H. (2017). Antidepressant use and risk of hip fractures among community dwelling persons with and without Alzheimer’s disease. International Journal of Geriatric Psychiatry, 32(12), e107-e115. https://doi.org/10.1002/gps.4667
dc.relation	Upala, S., & Sanguankeo, A. (2016). Association Between Hyponatremia, Osteoporosis, and Fracture: A Systematic Review and Meta-analysis. The Journal of Clinical Endocrinology and Metabolism, 101(4), 1880-1886. https://doi.org/10.1210/jc.2015-4228
dc.relation	Vida, S., Des Rosiers, P., Carrier, L., & Gauthier, S. (1994). Prevalence of depression in Alzheimer’s disease and validity of Research Diagnostic Criteria. Journal of Geriatric Psychiatry and Neurology, 7(4), 238-244. https://doi.org/10.1177/089198879400700409
dc.relation	Watt, J. A., Goodarzi, Z., Veroniki, A. A., Nincic, V., Khan, P. A., Ghassemi, M., Thompson, Y., Lai, Y., Treister, V., Tricco, A. C., & Straus, S. E. (2020). Safety of pharmacologic interventions for neuropsychiatric symptoms in dementia: A systematic review and network meta-analysis. BMC Geriatrics, 20. https://doi.org/10.1186/s12877-020-01607-7
dc.relation	WHO \| The global burden of disease: 2004 update. (s. f.). WHO; World Health Organization. Recuperado 11 de octubre de 2020, de https://www.who.int/healthinfo/global_burden_disease/2004_report_update/en/
dc.relation	Wilkinson, P., & Izmeth, Z. (2012). Continuation and maintenance treatments for depression in older people. The Cochrane Database of Systematic Reviews, 11, CD006727. https://doi.org/10.1002/14651858.CD006727.pub2
dc.relation	Wilkinson, P., & Izmeth, Z. (2016). Continuation and maintenance treatments for depression in older people. The Cochrane Database of Systematic Reviews, 9, CD006727. https://doi.org/10.1002/14651858.CD006727.pub3
dc.relation	Wilson, K. C. M., Mottram, P. G., Ashworth, L., & Abou-Saleh, M. T. (2003). Older community residents with depression: Long-term treatment with sertraline: Randomised, double blind, placebo-controlled study. The British Journal of Psychiatry, 182(6), 492-497. https://doi.org/10.1192/bjp.182.6.492
dc.relation	Wilson, K., Mottram, P. G., Sivananthan, A., & Nightingale, A. (2001). Antidepressants versus placebo for the depressed elderly. The Cochrane Database of Systematic Reviews, 2001(1). https://doi.org/10.1002/14651858.CD000561
dc.relation	World Population Prospects—Population Division—United Nations. (s. f.). Recuperado 5 de octubre de 2020, de https://population.un.org/wpp
dc.relation	Zhou, C., Fang, L., Chen, Y., Zhong, J., Wang, H., & Xie, P. (2018). Effect of selective serotonin reuptake inhibitors on bone mineral density: A systematic review and meta-analysis. Osteoporosis International: A Journal Established as Result of Cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 29(6), 1243-1251. https://doi.org/10.1007/s00198-018-4413-0
dc.relation	Ziere, G., Dieleman, J. P., van der Cammen, T. J. M., Hofman, A., Pols, H. A. P., & Stricker, B. H. C. (2008). Selective serotonin reuptake inhibiting antidepressants are associated with an increased risk of nonvertebral fractures. Journal of Clinical Psychopharmacology, 28(4), 411-417. https://doi.org/10.1097/JCP.0b013e31817e0ecb
dc.rights	http://creativecommons.org/licenses/by-nc-nd/2.5/co/
dc.rights	Abierto (Texto Completo)
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	http://purl.org/coar/access_right/c_abf2
dc.rights	Atribución-NoComercial-SinDerivadas 2.5 Colombia
dc.subject	Medical sciences
dc.subject	Health sciences
dc.subject	Elderly
dc.subject	Antidepressants
dc.subject	Evidence-based guidance
dc.subject	Depression
dc.subject	Pharmacology
dc.subject	Psychotropic drugs
dc.subject	Pathology
dc.subject	Ciencias médicas
dc.subject	Farmacología
dc.subject	Drogas psicotrópicas
dc.subject	Patología
dc.subject	Ciencias de la salud
dc.subject	Adulto mayor
dc.subject	Antidepresivos
dc.subject	Guía basada en evidencia
dc.subject	Depresión
dc.title	Tratamiento farmacológico antidepresivo en adultos mayores: Guía basada en síntesis de la evidencia
dc.title	Antidepressant drug treatment in older adults: Guidance based on evidence synthesis
dc.type	Thesis
dc.type	info:eu-repo/semantics/masterThesis
dc.type	Tesis
dc.type	http://purl.org/coar/resource_type/c_bdcc
dc.type	info:eu-repo/semantics/acceptedVersion
dc.type	http://purl.org/redcol/resource_type/TM
dc.coverage	Colombia