Specific combinations of inflammatory, angiogenesis and vascular integrity biomarkers are associated with clinical severity, coma and mortality in Beninese children with Plasmodium falciparum malaria

Tornyigah, B.; Blankson, S. O.; Adamou, R.; Moussiliou, A.; Rietmeyer, L.; Tettey, P.; Dikroh, L.; Addo, B.; Lamptey, H.; Alao, M. J.; Amoussou, A.; Padounou, C.; Roussilhon, C.; Pons, S.; Mensah, B. A.; /Tuikue Ndam, Nicaise; /Tahar, Rachida

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dc.creator	Tornyigah, B.
dc.creator	Blankson, S. O.
dc.creator	Adamou, R.
dc.creator	Moussiliou, A.
dc.creator	Rietmeyer, L.
dc.creator	Tettey, P.
dc.creator	Dikroh, L.
dc.creator	Addo, B.
dc.creator	Lamptey, H.
dc.creator	Alao, M. J.
dc.creator	Amoussou, A.
dc.creator	Padounou, C.
dc.creator	Roussilhon, C.
dc.creator	Pons, S.
dc.creator	Mensah, B. A.
dc.creator	/Tuikue Ndam, Nicaise
dc.creator	/Tahar, Rachida
dc.date	2022
dc.date.accessioned	2022-04-27T17:37:56Z
dc.date.available	2022-04-27T17:37:56Z
dc.identifier	https://www.documentation.ird.fr/hor/fdi:010084350
dc.identifier	oai:ird.fr:fdi:010084350
dc.identifier	Tornyigah B., Blankson S. O., Adamou R., Moussiliou A., Rietmeyer L., Tettey P., Dikroh L., Addo B., Lamptey H., Alao M. J., Amoussou A., Padounou C., Roussilhon C., Pons S., Mensah B. A., Tuikue Ndam Nicaise, Tahar Rachida. Specific combinations of inflammatory, angiogenesis and vascular integrity biomarkers are associated with clinical severity, coma and mortality in Beninese children with Plasmodium falciparum malaria. 2022, 12 (2), p. 524 [17 p.]
dc.identifier.uri	http://biblioteca-repositorio.clacso.edu.ar/handle/CLACSO/169173
dc.description	Malaria-related deaths could be prevented if powerful diagnostic and reliable prognostic biomarkers were available to allow rapid prediction of the clinical severity allowing adequate treatment. Using quantitative ELISA, we assessed the plasma concentrations of Procalcitonin, Pentraxine-3, Ang-2, sTie-2, suPAR, sEPCR and sICAM-1 in a cohort of Beninese children with malaria to investigate their potential association with clinical manifestations of malaria. We found that all molecules showed higher levels in children with severe or cerebral malaria compared to those with uncomplicated malaria (p-value < 0.005). Plasma concentrations of Pentraxine-3, Procalcitonin, Ang-2 and the soluble receptors were significantly higher in children with coma as defined by a Blantyre Coma Score < 3 (p < 0.001 for Pentraxine-3, suPAR, and sTie-2, p = 0.004 for PCT, p = 0.005 for sICAM-1, p = 0.04 for Ang-2). Moreover, except for the PCT level, the concentrations of Pentraxine-3, suPAR, sEPCR, sICAM-1, sTie-2 and Ang-2 were higher among children who died from severe malaria compared to those who survived (p = 0.037, p = 0.035, p < 0.0001, p= 0.0008, p = 0.01 and p = 0.02, respectively). These findings indicate the ability of these molecules to accurately discriminate among clinical manifestations of malaria, thus, they might be potentially useful for the early prognostic of severe and fatal malaria, and to improve management of severe cases.
dc.language	EN
dc.subject	cerebral malaria
dc.subject	biomarkers
dc.subject	sICAM-1
dc.subject	EPCR
dc.subject	PTX3
dc.subject	PCT
dc.subject	suPAR
dc.subject	sTie-2
dc.subject	Ang-2
dc.title	Specific combinations of inflammatory, angiogenesis and vascular integrity biomarkers are associated with clinical severity, coma and mortality in Beninese children with Plasmodium falciparum malaria
dc.type	text
dc.coverage	BENIN