Efficacy of careHPV (TM) human papillomavirus screening versus conventional cytology tests for the detection of precancerous and cancerous cervical lesions among women living with HIV-1 in Lao People's Democratic Republic

Paboriboune, P.; Phongsavan, K.; Arounlangsy, P.; Flaissier, B.; Aphayarath, O.; Phimmasone, P.; Banchongphanith, K.; Xayaovong, M.; /Jourdain, Gonzague; Schott, A. M.; Saadatian-Elahi, M.; Magaud, L.; Klich, A.; /Ngo-Giang-Huong, Nicole; Heard, I.; Rabilloud, M.; Picot, V. S.; Longuet, C.

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dc.creator	Paboriboune, P.
dc.creator	Phongsavan, K.
dc.creator	Arounlangsy, P.
dc.creator	Flaissier, B.
dc.creator	Aphayarath, O.
dc.creator	Phimmasone, P.
dc.creator	Banchongphanith, K.
dc.creator	Xayaovong, M.
dc.creator	/Jourdain, Gonzague
dc.creator	Schott, A. M.
dc.creator	Saadatian-Elahi, M.
dc.creator	Magaud, L.
dc.creator	Klich, A.
dc.creator	/Ngo-Giang-Huong, Nicole
dc.creator	Heard, I.
dc.creator	Rabilloud, M.
dc.creator	Picot, V. S.
dc.creator	Longuet, C.
dc.date	2022
dc.date.accessioned	2022-04-27T17:37:52Z
dc.date.available	2022-04-27T17:37:52Z
dc.identifier	https://www.documentation.ird.fr/hor/fdi:010084385
dc.identifier	oai:ird.fr:fdi:010084385
dc.identifier	Paboriboune P., Phongsavan K., Arounlangsy P., Flaissier B., Aphayarath O., Phimmasone P., Banchongphanith K., Xayaovong M., Jourdain Gonzague, Schott A. M., Saadatian-Elahi M., Magaud L., Klich A., Ngo-Giang-Huong Nicole, Heard I., Rabilloud M., Picot V. S., Longuet C.. Efficacy of careHPV (TM) human papillomavirus screening versus conventional cytology tests for the detection of precancerous and cancerous cervical lesions among women living with HIV-1 in Lao People's Democratic Republic. 2022, [Early access], p. [11 p.]
dc.identifier.uri	http://biblioteca-repositorio.clacso.edu.ar/handle/CLACSO/169141
dc.description	Background: In the Lao People's Democratic Republic (Lao PDR), cervical cancer is the third leading cause of women cancer. Aims: The objective of this cross-sectional study was to compare the efficacy of careHPV (TM) test versus conventional Pap smear or Siriraj liquid-based cytology in the detection of cervical cancer in women living with human immunodeficiency virus type 1 (HIV-1). Materials & Methods: Overall, 631 women consented to participate. Four cervical specimens were taken for the purpose of conventional Pap smear, Siriraj liquid-based cytology, careHPV (TM) test, and HPV-16 genotyping. The exact McNemar test was used to compare the efficacy and diagnostic performance of the tests. Results: Of the 631 women with follow-up, 331 were human papillomavirus (HPV) negative. High-grade squamous intraepithelial lesions were found in 37 women, biopsy-proven high-grade cervical intraepithelial neoplasia in 50 women, and invasive carcinoma in seven women. The proportion of women with high-grade cervical lesion or carcinoma detected after abnormal careHPV (TM) test was higher (6.02%; 95% confidence interval [CI]: 4.4-8.1) than that detected by conventional Pap smear (4.59%; 95% CI: 3.2-6.5). careHPV (TM) and HPV-16 genotyping had, respectively, the highest sensitivity (80.8%; 95% CI: 67.4-89.5) and specificity (92.2%; 95% CI: 89.8-94.2). HPV-16 was the most frequently detected genotype. Conclusions: careHPV (TM) test represents a screening option in Lao PDR, particularly in women living with HIV-1 because of higher prevalence of chronic HPV in this population.
dc.language	EN
dc.subject	careHPV (TM)
dc.subject	cervical cancer
dc.subject	HIV-1
dc.subject	Lao PDR
dc.subject	liquid-based cytology
dc.subject	Papanicolaou test
dc.title	Efficacy of careHPV (TM) human papillomavirus screening versus conventional cytology tests for the detection of precancerous and cancerous cervical lesions among women living with HIV-1 in Lao People's Democratic Republic
dc.type	text
dc.coverage	LAOS