The SARS-CoV-2 Alpha variant exhibits comparable fitness to the D614G strain in a Syrian hamster model

Cochin, M.; Luciani, L.; Touret, F.; Driouich, J. S.; Petit, P. R.; Moureau, G.; /Baronti, Cécile; Laprie, C.; /Thirion, Laurence; Maes, P.; Boudewijns, R.; Neyts, J.; Lamballerie, X. de; Nougairede, A.

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dc.creator	Cochin, M.
dc.creator	Luciani, L.
dc.creator	Touret, F.
dc.creator	Driouich, J. S.
dc.creator	Petit, P. R.
dc.creator	Moureau, G.
dc.creator	/Baronti, Cécile
dc.creator	Laprie, C.
dc.creator	/Thirion, Laurence
dc.creator	Maes, P.
dc.creator	Boudewijns, R.
dc.creator	Neyts, J.
dc.creator	Lamballerie, X. de
dc.creator	Nougairede, A.
dc.date	2022
dc.date.accessioned	2022-04-27T17:37:48Z
dc.date.available	2022-04-27T17:37:48Z
dc.identifier	https://www.documentation.ird.fr/hor/fdi:010084502
dc.identifier	oai:ird.fr:fdi:010084502
dc.identifier	Cochin M., Luciani L., Touret F., Driouich J. S., Petit P. R., Moureau G., Baronti Cécile, Laprie C., Thirion Laurence, Maes P., Boudewijns R., Neyts J., Lamballerie X. de, Nougairede A.. The SARS-CoV-2 Alpha variant exhibits comparable fitness to the D614G strain in a Syrian hamster model. 2022, 5 (1), p. 225 [8 p.]
dc.identifier.uri	http://biblioteca-repositorio.clacso.edu.ar/handle/CLACSO/169099
dc.description	The SARS-CoV-2 Alpha variant exhibits similar transmission dynamics to an ancestral D614G variant in a Syrian hamster model, suggesting the limitations of using the hamster as the sole model to assess differences between SARS-CoV-2 strains. Late 2020, SARS-CoV-2 Alpha variant emerged in United Kingdom and gradually replaced G614 strains initially involved in the global spread of the pandemic. In this study, we use a Syrian hamster model to compare a clinical strain of Alpha variant with an ancestral G614 strain. The Alpha variant succeed to infect animals and to induce a pathology that mimics COVID-19. However, both strains replicate to almost the same level and induced a comparable disease and immune response. A slight fitness advantage is noted for the G614 strain during competition and transmission experiments. These data do not corroborate the epidemiological situation observed during the first half of 2021 in humans nor reports that showed a more rapid replication of Alpha variant in human reconstituted bronchial epithelium. This study highlights the need to combine data from different laboratories using various animal models to decipher the biological properties of newly emerging SARS-CoV-2 variants.
dc.language	EN
dc.title	The SARS-CoV-2 Alpha variant exhibits comparable fitness to the D614G strain in a Syrian hamster model
dc.type	text
dc.coverage	SYRIE