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Título :	Protective role of ginger and curcumin against some toxicological effects induced by thermoxidized frying cotton oil Protective role of ginger and curcumin against some toxicological effects induced by thermoxidized frying cotton oil
Palabras clave :	thermoxidized frying cotton oil;ginger;curcumin;biochemical changes;chromosomal aberrations;histopathological changes;thermoxidized frying cotton oil;ginger;curcumin;biochemical changes;chromosomal aberrations;histopathological changes
Editorial :	Federal University of Piauí
Descripción :	In Egypt, the bad economic situation in many homes often demand that oil previously fried is reused and this may constitute health risk to consumers. The aim of the present work was to investigate the protective role of ginger and curcumin powders against some toxicological effects of thermoxidized frying cotton oil (OFO). Thirty five male albino rats were divided into seven groups: negative control, ginger-treated group (1 g/100 g in diet), curcumin treated group (0.2 g/100 g diet), fresh cotton oil treated group (15 mL/kg orally), OFO – treated group (15 mL/kg orally), OFO (15 mL/kg orally) + ginger (1 g/100 g in diet) – treated group and OFO (15 mL/kg orally) + curcumin (0.2% in diet) – treated group. After 28 days of experiment, the results indicated that OFO treated group showed significant (p≤ 0.05) increase in both liver enzymes (AST and ALT) and glucose levels. Significant increase in the frequencies of chromosomal aberrations in somatic and germ cells were encountered. Histopathological changes in liver in form of fatty changes and central vein congestion were observed. The addition of ginger or curcumin to diet of OFO treated group produced improvement in the liver function, decrease in the glucose level, increase in the level of total antioxidants, reduction in the frequencies of chromosomal aberrations and improvement of the hepatic pathological changes.  In conclusion, ginger and curcumin can protect against toxicity of frying oil, but, curcumin needs further investigation to find the effective and safe dose. In Egypt, the bad economic situation in many homes often demand that oil previously fried is reused and this may constitute health risk to consumers. The aim of the present work was to investigate the protective role of ginger and curcumin powders against some toxicological effects of thermoxidized frying cotton oil (OFO). Thirty five male albino rats were divided into seven groups: negative control, ginger-treated group (1 g/100 g in diet), curcumin treated group (0.2 g/100 g diet), fresh cotton oil treated group (15 mL/kg orally), OFO – treated group (15 mL/kg orally), OFO (15 mL/kg orally) + ginger (1 g/100 g in diet) – treated group and OFO (15 mL/kg orally) + curcumin (0.2% in diet) – treated group. After 28 days of experiment, the results indicated that OFO treated group showed significant (p≤ 0.05) increase in both liver enzymes (AST and ALT) and glucose levels. Significant increase in the frequencies of chromosomal aberrations in somatic and germ cells were encountered. Histopathological changes in liver in form of fatty changes and central vein congestion were observed. The addition of ginger or curcumin to diet of OFO treated group produced improvement in the liver function, decrease in the glucose level, increase in the level of total antioxidants, reduction in the frequencies of chromosomal aberrations and improvement of the hepatic pathological changes.  In conclusion, ginger and curcumin can protect against toxicity of frying oil, but, curcumin needs further investigation to find the effective and safe dose Função protetora de gengibre e curcumina contra alguns efeitos toxicológicos induzidos por óleo de algodão frito termoxidadoResumoNo Egito, a má situação econômica em muitos lares, geralmente exige que o óleo previamente frito seja utilizado novamente o que pode constituir um risco para a saúde dos consumidores. O objetivo do presente trabalho foi investigar o papel protetor de gengibre e curcumina contra alguns efeitos toxicológicos do óleo de algodão frito termoxidado (OFO). Trinta e cinco ratos albinos machos foram divididos em sete grupos: controle negativo, grupo tratado com gengibre (1 g/100 g de dieta), grupo tratado com curcumina (0,2 g/100 g de dieta), grupo tratado com óleo de algodão fresco (15 mL/kg por via oral), OFO grupo tratado (15 mL/kg por via oral), OFO (15 mL/kg por via oral) + gengibre (1 g/100 g de dieta) e OFO (15 mL/kg por via oral) + curcumina (0,2 % na dieta). Após 28 dias de experimento, os resultados indicaram que o grupo tratado com OFO apresentou significativo aumento (p ≤ 0,05) de ambas as enzimas do fígado (AST e ALT) e níveis de glicose. Aumento significativo nas freqüências de aberrações cromossômicas em células somáticas e germinativas foi observado. Alterações histopatológicas no fígado em forma de modificações de gordura e congestão venosa central foram identificadas. O grupo tratado com adição de gengibre ou curcumina à dieta de OFO produziu melhoria na função hepática, diminuição do nível de glicose, aumento do nível de antioxidantes totais, redução da freqüência de aberrações cromossômicas e melhoria das alterações hepáticas patológicas. Em conclusão, gengibre e curcumina podem proteger contra a toxicidade do óleo de fritura, mas, a curcumina necessita de mais pesquisas para encontrar a dose eficaz e segura para seu uso.
URI :	http://biblioteca-repositorio.clacso.edu.ar/handle/CLACSO/77470
Otros identificadores :	https://comunicatascientiae.com.br/comunicata/article/view/7 10.14295/cs.v1i1.7
Aparece en las colecciones:	Núcleo de Pesquisa sobre Crianças, Adolescestes e Jovens - Universidade Federal do Piauí - NUPEC/UFPI - Cosecha

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